This is the 538th most frequent Chinese word.
指示
"指示" means "instruction" or "directive."
In this sentence, '指示' is used to mean 'instructions' or 'directions', often from someone in authority.
老板发来了新的指示，请大家注意。
The boss has sent new instructions, so please pay attention.
In this case, '指示' means 'indicate' or 'signify', often related to navigational or directional signs.
道路旁的标牌用来指示方向。
The signpost by the road is used to indicate directions.
Here, '指示' is used in the sense of 'indicate' or 'point out', referring to giving evidence or signs.