This is the 70th most frequent German word.
ende
"Ende" means "end" in English.
Here, 'Ende' is used in the phrase 'Am Ende' to denote the point in time when the day concludes.
Am Ende des Tages bin ich immer müde.
At the end of the day, I am always tired.
In this sentence, 'Ende' is used to denote the final sequence or concluding part of the film.
Das Ende des Films war sehr überraschend.
The ending of the film was very surprising.
In this case, 'Wochenende' is a compound word where 'Ende' contributes its meaning of 'end' as part of discussing the end of the week.