This is the 1126th most frequent German word.
wichtigsten
"Most important."
Here, 'wichtigsten' acts as a superlative adjective (the most important), agreeing with the noun 'Buch'.
Das wichtigste Buch auf meiner Liste ist sehr informativ.
The most important book on my list is very informative.
'Wichtigsten' is used here as a superlative adjective within a genitive case construction describing 'Gründe'.
Einer der wichtigsten Gründe für meinen Umzug war die bessere Lebensqualität.
One of the most important reasons for my move was the better quality of life.
'Wichtigsten' in this sentence modifies 'Themen' in the plural, indicating the topics that are most significant among others.