This is the 525th most frequent Italian word.
differenza
"Difference."
In this case, 'differenza' is employed as a noun to indicate irrelevance or lack of impact.
Non fa alcuna differenza quale strada scegli.
It does not make any difference which road you choose.
Here, 'differenza' signifies a variation or diversity, specifically in perspectives.
La differenza di opinione arricchisce il dialogo.
The difference in opinion enriches the dialogue.
Here, 'differenza' is used as a noun to denote a distinction between two entities.