This is the 417th most frequent Italian word.
vanno
"Vanno" means "they go."
Here, 'vanno' metaphorically represents the way conditions or situations progress or occur.
Le cose non vanno come previsto.
Things are not going as planned.
In this context, 'vanno' conveys necessity or recommendation, akin to 'should be' or 'must be' in English.
I pantaloni vanno lavati a mano.
The trousers should be hand-washed.
In this sentence, 'vanno' is the third-person plural conjugation of the verb 'andare' (to go), used here to indicate regular activity or movement to a destination.