This is the 389th most frequent Japanese word.
人生
"人生" means "life" or "human life."
Here, '人生' (jinsei, 'life') refers to the general concept of human life as an experience or a story.
人生は旅とよく言われます。
Life is often compared to a journey.
In this sentence, '人生' (jinsei) represents an individual's specific life journey or circumstances.
彼はその事故で人生が変わってしまった。
His life was changed by that accident.
Here, '人生' (jinsei) is used in the abstract sense of life as the context in which goals and aspirations exist.