This is the 4408th most frequent Japanese word.
喪失
"Loss" or "forfeiture."
The word 喪失 (loss) is used here to describe the loss of a job.
彼は職を喪失した後、長い間苦労しました。
He struggled for a long time after losing his job.
喪失 (loss) is referring to a profound sense of loss experienced by others upon her passing.
彼女の突然の死により、大きな喪失感が広がった。
Her sudden death caused a great sense of loss.
喪失 (loss) is used to describe the loss of memory as a condition.