This is the 4539th most frequent Japanese word.
巨人
"巨人" means "giant" or "titan" in English.
In this sentence, 巨人 refers to literal giants, mythical beings of enormous size.
あの映画には巨人が登場します。
That movie features giants.
Here, 巨人 is the name of a baseball team, referring to a proper noun.
彼は野球チーム、巨人のファンです。
He is a fan of the baseball team Giants.
In this context, 巨人 is used metaphorically, comparing accomplishment to the grand stature of giants.