This is the 2609th most frequent Japanese word.
手放す
"手放す" means "to let go" or "to release."
Here, "手放す" is used to mean "let go" or "give up" something, specifically referring to relinquishing ownership of an item.
彼は古い車を手放すことにした。
He decided to let go of his old car.
In this sentence, "手放す" conveys a reluctance to lose or end an emotional connection or relationship.
私は彼女との関係を手放したくない。
I don't want to let go of the relationship with her.
Here, "手放す" is applied to the metaphorical letting go of negative emotions or hindrances in order to move forward.