This is the 4634th most frequent Japanese word.
押さえ
"押さえ" means "control," "restraint," or "hold down."
Here, 押さえながら means 'while focusing on' or 'holding down in relevance to an abstract concept'.
重要なポイントを押さえながら勉強しましょう。
Let's study while focusing on the important points.
Here, 押さえて means 'press firmly' or 'hold down' in relation to a physical object.
このボタンを押さえて、機械を動かしてください。
Hold down this button to operate the machine.
Here, 押さえ means 'to hold firmly or keep down physically'.