This is the 2627th most frequent Japanese word.
支障
Obstacle; hindrance; difficulty.
The word '支障' is used here to denote 'obstacle' or 'hindrance' within the context of progress or plans being implemented.
予定通りに作業を進める上で何の支障もありませんでした。
There were no obstacles in proceeding with the work as planned.
'支障' in this sentence reflects 'hindrance' or 'interference' that his health might create in the context of work.
彼の健康問題が仕事に支障を来たすかもしれません。
His health issues may hinder his work.
Here, '支障' refers to 'disturbances' or 'issues' in the context of implementing a new system.