This is the 4804th most frequent Japanese word.
汚れ
Dirt, stain, or impurity.
In this sentence, '汚れ' is used to indicate a physical stain or dirt on the clothes.
服に汚れがついている。
There is dirt on the clothes.
'汚れ' refers to a spot or mark that needs to be cleaned here.
この汚れをどうやって落とせば良いですか？
How can I remove this stain?
Here, '汚れ' is used metaphorically to mean impurity or corruption in a figurative sense.