This is the 69th most frequent Malay word.
sejak
Since.
In this sentence, 'sejak' specifies the starting point of when the action (knowing him) began.
Saya telah mengenali dia sejak zaman sekolah.
I have known him since school.
Here, 'sejak' indicates the time following an event (the rain stopping).
Sejak hujan berhenti, langit menjadi cerah.
Since the rain stopped, the sky has become clear.
In this context, 'sejak' is used to show the start of a change (improvement) due to an action (taking new medication).