This is the 2381st most frequent Spanish word.
arequipa
"Arequipa" is the name of a city in southern Peru.
In this sentence, 'Arequipa' is used as a proper noun referring to a specific geographic location.
Arequipa es una ciudad hermosa en Perú.
Arequipa is a beautiful city in Peru.
Here, 'arequipeño' is an adjective derived from 'Arequipa' that describes something originating from or connected to that place.
El queso arequipeño es famoso por su sabor.
The Arequipa-style cheese is famous for its flavor.
In this case, 'Arequipa' is used again as a proper noun representing the name of a place someone plans to visit.